Anti-SLC1A4 Antibody Picoband® fluoro488 Vervoeging

Neutral amino acid transporter A, also called SLC1A4 or ASCT1, is a protein that in humans is encodes by the SLC1A4 gene. The SLC1A4 gene is mapped to chromosome 2p14 based on an alignment of the SLC1A4 sequence with the genomic sequence (GRCh37) . ASCT1 does not transport glutamate or aspartate but alanine, serine, cysteine, and threonine instead. It is found that the ASCT1 transporter functions primarily as an amino acid exchanger. Transport is associated with a chloride channel activity that is thermodynamically uncoupled from animo acid transport. This gene also exhibits sodium dependence.

Neutral amino acid transporter A; Alanine/serine/cysteine/threonine transporter 1; ASCT-1; SATT; Solute carrier family 1 member 4; SLC1A4; ASCT1, SATT

SLC1A4

6509

P43007

Rat, Mouse, Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human SLC1A4, different from the related rat and mouse sequences by one amino acid.

Expressed mostly in brain, muscle, and pancreas but detected in all tissues examined.

Flow Cytometry

Amino Acid Metabolism, Amino Acids, Channels, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Plasma Membrane, Signal Transduction

Immunogen affinity purified.

Liquid

Transporter for alanine, serine, cysteine, and threonine. Exhibits sodium dependence.

1. Arriza, J. L., Kavanaugh, M. P., Fairman, W. A., Wu, Y.-N., Murdoch, G. H., North, R. A., Amara, S. G. Cloning and expression of a human neutral amino acid transporter with structural similarity to the glutamate transporter gene family. J. Biol. Chem. 268: 15329-15332, 1993. 2. Shafqat, S., Tamarappoo, B. K., Kilberg, M. S., Puranam, R. S., McNamara, J. O., Guadano-Ferraz, A., Fremeau, R. T., Jr. Cloning and expression of a novel Na (+) -dependent neutral amino acid transporter structurally related to mammalian Na (+) /glutamate cotransporters. J. Biol. Chem. 268: 15351-15355, 1993.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

55723 MW

No cross reactivity with other proteins.

6

Neutral amino acid transporter A

Membrane ; Multi-pass membrane protein . Melanosome . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.

Neutral amino acid transporter A

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.