Anti-Slc35D1 Antilichaam

The solute carrier family Slc35 consists of at least 17 proteins that act as nucleotide sugar transporters localized to the Golgi apparatus and endoplasmic reticulum. The role of the ER-resident Slc family member Slc35D1 is to transport both UDP-glucuronic acid and UDP-N-acetylgalactosamine. These molecules can serve as substrates for chondroitin sulfate biosynthesis and mice lacking the Slc35D1 gene developed a lethal form of skeletal dysplasia with severe shortening of limbs and facial structures. Examination of epiphyseal cartilage in these mice revealed a decreased proliferating zone with round chrondrocytes, scarce matrices, and reduced proteoglycan aggregates. Loss of function mutations in human Slc35D1 cause Schneckenbecken dysplasia, a severe skeletal dysplasia.

Boster Bio Anti-Slc35D1 Antibody (Catalog # A11935) . Tested in ELISA, WB, ICC applications. This antibody reacts with Human.

UGTREL7, KIAA0260, UGTREL7, Solute carrier family 35 member D1, UGTrel7

SLC35D1

Q9NTN3

Human

This antibody is predicted to not cross-react with the highly homologous Slc35D2.

Slc35D1 antibody was raised against a 20 amino acid synthetic peptide near the carboxy terminus of the human Slc35D1. The immunogen is located within the last 50 amino acids of Slc35D1.

Ubiquitous.

ELISA, WB, ICC

Homeostasis

Slc35D1 Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Transports both UDP-glucuronic acid (UDP-GlcA) and UDP- N-acetylgalactosamine (UDP-GalNAc) from the cytoplasm into the endoplasmic reticulum lumen (PubMed:11322953, PubMed:17952091) . Plays a role in chondroitin sulfate biosynthesis, which is important for formation of cartilage extracellular matrix and normal skeletal development (By similarity) .

Slc35D1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

https://www.bosterbio.com/msds?sku=A11935

39240 MW

Solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1

Endoplasmic reticulum membrane

Bovine, Pig

Solute carrier family 35 (UDP-glucuronic acid/UDP-N-acetylgalactosamine dual transporter), member D1

IgG

Slc35D1 Antibody is supplied in PBS containing 0.02% sodium azide.