Anti-SLC3A1 Antibody Picoband® fluoro550 Vervoeging

Neutral and basic amino acid transport protein rBAT is a protein that in humans is encoded by the SLC3A1 gene. This gene encodes a type II membrane glycoprotein which is one of the components of the renal amino acid transporter which transports neutral and basic amino acids in the renal tubule and intestinal tract. Mutations and deletions in this gene are associated with cystinuria. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Dermatopontin; Tyrosine-rich acidic matrix protein; TRAMP; DPT

SLC3A1

6519

Q07837

Human, Monkey, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human SLC3A1 recombinant protein (Position: K70-R665) .

Expressed in fibroblasts, heart, skeletal muscle, brain and pancreas. Expressed at an intermediate level in lung and kidney, and at a low level in liver and placenta. Expressed at a lower level in fibroblasts from hypertrophic scar lesional skin and in fibroblasts from patients with systemic sclerosis than in normal skin fibroblasts.

Flow Cytometry

Biochemicals, Chemical Type, Signal Transduction

Immunogen affinity purified.

Liquid

Seems to mediate adhesion by cell surface integrin binding. May serve as a communication link between the dermal fibroblast cell surface and its extracellular matrix environment. Enhances TGFB1 activity. Inhibits cell proliferation. Accelerates collagen fibril formation, and stabilizes collagen fibrils against low-temperature dissociation (By similarity) .

1. Barbosa, M., Lopes, A., Mota, C., Martins, E., Oliveira, J., Alves, S., De Bonis, P., do Ceu Mota, M., Dias, C., Rodrigues-Santos, P., Fortuna, A. M., Quelhas, D., Lacerda, L., Bisceglia, L., Cardoso, M. L. Clinical, biochemical and molecular characterization of cystinuria in a cohort of 12 patients. Clin. Genet. 81: 47-55, 2012. 2. Bartoccioni, P., Rius, M., Zorzano, A., Palacin, M., Chillaron, J. Distinct classes of trafficking rBAT mutants cause the type I cystinuria phenotype. Hum. Molec. Genet. 17: 1845-1854, 2008. 3. Bisceglia, L., Calonge, M. J., Strologo, L. D., Rizzoni, G., de Sanctis, L., Gallucci, M., Beccia, E., Testar, X., Zorzano, A., Estivill, X., Zelante, L., Palacin, M., Gasparini, P., Nunes, V. Molecular analysis of the cystinuria disease gene: identification of four new mutations, one large deletion, and one polymorphism. Hum. Genet. 98: 447-451, 1996.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

33310 MW

6

Dermatopontin

Secreted, extracellular space, extracellular matrix.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.