Anti-SLU7 Antibody Picoband® 31.0550 Vervoeging

Pre-mRNA-splicing factor SLU7 is a protein that in humans is encoded by the SLU7 gene. Pre-mRNA splicing occurs in two sequential transesterification steps. The protein encoded by this gene is a splicing factor that has been found to be essential during the second catalytic step in the pre-mRNA splicing process. It associates with the spliceosome and contains a zinc knuckle motif that is found in other splicing factors and is involved in protein-nucleic acid and protein-protein interactions.

C-C motif chemokine 16; Chemokine CC-4; HCC-4; Chemokine LEC; IL-10-inducible chemokine; LCC-1; Liver-expressed chemokine; Lymphocyte and monocyte chemoattractant; LMC; Monotactin-1; MTN-1; NCC-4; Small-inducible cytokine A16; CCL16; ILINCK; NCC4; SCYA16

SLU7

10569

O95391

Human

No cross-reactivity with other proteins.

E.coli-derived human SLU7 recombinant protein (Position: Q42-I474) .

Mainly expressed in liver, also found in spleen and thymus. Highly expressed in LPS- and IFN-gamma- activated monocytes, weakly in some lymphocytes, including natural killer cells, gamma-delta T-cells, and some T-cell clones.

Flow Cytometry

Angiogenesis, Cardiovascular, Chemokines, Cytokines, Immunology, Innate Immunity, Macrophage/Inflammation

Immunogen affinity purified.

Liquid

Shows chemotactic activity for lymphocytes and monocytes but not neutrophils. Also shows potent myelosuppressive activity, suppresses proliferation of myeloid progenitor cells. Recombinant SCYA16 shows chemotactic activity for monocytes and THP-1 monocytes, but not for resting lymphocytes and neutrophils. Induces a calcium flux in THP-1 cells that were desensitized by prior expression to RANTES.

1. Chua, K., Reed, R. Human step II splicing factor hSlu7 functions in restructuring the spliceosome between the catalytic steps of splicing. Genes Dev. 13: 841-850, 1999. 2. Chua, K., Reed, R. The RNA splicing factor hSlu7 is required for correct 3-prime splice-site choice. Nature 402: 207-210, 1999. 3. Lev-Maor, G., Sorek, R., Shomron, N., Ast, G. The birth of an alternatively spliced exon: 3-prime splice-site selection in Alu exons. Science 300: 1288-1291, 2003.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

157578 MW

6

C-C motif chemokine ligand 16

Secreted.

BAG family molecular chaperone regulator 5

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.