Anti-Sm-D3/SNRPD3 Antibody Picoband® 0,00647 Vervoeging

Small nuclear ribonucleoprotein Sm D3 is a protein that in humans is encoded by the SNRPD3 gene. This gene encodes a core component of the spliceosome, which is a nuclear ribonucleoprotein complex that functions in pre-mRNA splicing. Alternative splicing results in multiple transcript variants.

Mediator of RNA polymerase II transcription subunit 20; Mediator complex subunit 20; TRF-proximal protein homolog; hTRFP; MED20; TRFP

SNRPD3

6634

P62318

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human Sm-D3/SNRPD3 recombinant protein (Position: M1-R112) .

Pre-B-cells and B-cells but not terminally differentiated plasma cells.

Flow Cytometry

Epigenetics and Nuclear Signaling, Mediator Complex, Transcription

Immunogen affinity purified.

Liquid

Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.

1. Lehmeier, T., Raker, V., Hermann, H., Luhrmann, R. cDNA cloning of the Sm proteins D2 and D3 from human small nuclear ribonucleoproteins: evidence for a D1-D2 interaction. Proc. Nat. Acad. Sci. 91: 12317-12321, 1994.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

CD72 molecule

Nucleus .

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.