Anti-Smac/Diablo Konijn Monoklonale Antilichaam

Boster Bio Anti-Smac/Diablo Rabbit Monoclonal Antibody catalog # M03790. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Diablo homolog, mitochondrial; IAP-binding protein with low pI; Second mitochondria-derived activator of caspase; Smac; DIABLO; SMAC

DIABLO

56616

Q9NR28

Human, Mouse, Rat

A synthesized peptide derived from human Smac/Diablo

Clone: FGG-4

Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed. .

WB, IHC, ICC, IF, IP, Flow Cytometry

Apoptosis, Cancer, Cell Biology, Cell Death, Invasion/Microenvironment, Metabolism, Metabolism Processes, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Receptors

Affinity-chromatography

0.5mg/ml

Liquid

Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP) . Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis- inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M03790

27131 MW

54 kDa

Diablo homolog, mitochondrial

Mitochondrion . Released into the cytosol when cells undergo apoptosis.

T-cell surface glycoprotein CD3 zeta chain

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.