Anti-Smad1 Antibody Picoband® 31.0550 Vervoeging

Mothers against decapentaplegic homolog 1 also known as SMAD family member 1 or SMAD1 is a protein that in humans is encoded by the SMAD1 gene. SMAD1 belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene mothers against decapentaplegic (Mad) and the C. elegans gene Sma. The gene was assigned to human chromosome 4q31.21. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways.

Mothers against decapentaplegic homolog 1; MAD homolog 1; Mothers against DPP homolog 1; Dwarfin-A; Dwf-A; Mothers-against-DPP-related 1; Mad-related protein 1; mMad1; SMAD family member 1; SMAD 1; Smad1; Smad1; Madh1, Madr1

SMAD1

17125

P70340

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of mouse Smad1, different from the related rat sequence by one amino acid, and different from the related human sequence by two amino acids.

Ubiquitous.

Flow Cytometry

Cancer, Cancer Metabolism, Cytoplasmic, Epigenetics and Nuclear Signaling, Growth Factors, Metabolism, Metabolism Processes, Nuclear Signaling, Nuclear Signaling Pathways, Pathways and Processes, Response To Hypoxia, Signal Transduction, Signaling Pathway, Stem Cells, TGF Beta

Immunogen affinity purified.

Liquid

Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor-regulated SMAD (R-SMAD) (By similarity) . May play a role in the initiation and maintenance of spermatogenesis. SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1 (By similarity) . May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP) -mediated cardiac-specific gene expression (PubMed:15329343) . .

1. Hoodless PA, Haerry T, Abdollah S, Stapleton M, O'Connor MB, Attisano L, Wrana JL (May 1996) . MADR1, a MAD-related protein that functions in BMP2 signaling pathways. Cell 85 (4) : 489–500. 2. Riggins GJ, Thiagalingam S, Rozenblum E, Weinstein CL, Kern SE, Hamilton SR, Willson JK, Markowitz SD, Kinzler KW, Vogelstein B (July 1996) . Mad-related genes in the human. Nat. Genet. 13 (3) : 347–9. 3. Entrez Gene: SMAD1 SMAD family member 1. 4. Interactive fly, Drosophila.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

52157 MW

No cross reactivity with other proteins.

6

Mothers against decapentaplegic homolog 1

Cytoplasm . Nucleus . In the cytoplasm in the absence of ligand. Migration to the nucleus when complexed with SMAD4. Colocalizes with LEMD3 at the nucleus inner membrane (By similarity) . .

Belongs to the dwarfin/SMAD family.

Mothers against decapentaplegic homolog 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.