Anti-SMAD7 (N-terminaal gebied) Antilichaam

SMADs are members of the MAD-related family of molecules. MAD-related proteins are a family of intracellular proteins that are essential components in the signaling pathways of the serine/threonine kinase receptors of the transforming growth factor beta superfamily. SMADs can be divided into receptor-regulated SMADs (R-SMADs: SMAD1, 2, 3. 5 and 8), common-mediator SMAD (co-SMAD: SMAD4), and inhibitory SMADs (I-SMADs: SMAD6 and 7) . Briefly, activated type I receptors associate with specific R-Smads and phosphorylate them on a conserved SSXS motif at the carboxy-terminus of the proteins. The phosphorylated R-Smad dissociates from the receptor and forms a heteromeric complex with the co-Smad, Smad4, and together the complex moves to the nucleus. Once in the nucleus, Smads can target a variety of DNA binding proteins to regulate transcriptional responses.

Our SMAD7 (N-terminal region) primary antibody from PhosphoSolutions is rabbit polyclonal. It detects human, mouse, rat, and xenopus SMAD7 (N-terminal region) and is protein g purified. It is great for use in ELISA, WB, ICC.

Our SMAD7 (N-terminal region) primary antibody from PhosphoSolutions is rabbit polyclonal. It detects human, mouse, rat, and Xenopus SMAD7 (N-terminal region) and is Protein G purified. It is great for use in WB, ICC.

MADH7, MADH8, MAD7

SMAD7

O15105

Human, Mouse, Rat, and Xenopus

This antibody was raised against amino acids from the N-terminal region of human SMAD7. This sequence is 100% or highly conserved between human and multiple species.

SMAD7 (N-terminal region)

Unconjugated

ELISA, WB, ICC

Apoptosis, Cell Signaling, Cytoskeletal Regulation

Protein G Purified

PBS + 0.05% BSA and 0.05% NaN3

46

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Blue Ice

Recommended that the undiluted antibody be aliquoted into smaller working volumes (10-30 uL/vial depending on usage) upon arrival and stored long term at -20° C or -80° C, while keeping a working aliquot stored at 4° C for short term. Avoid freeze/thaw cycles. Stable for at least 1 year.

Protein G purified culture supernatant.

1:500

This antibody detects SMAD7 at 46 kDa* on SDS-PAGE immunoblots of human Jurkat cells and mouse C2C12. The antibody can used for western blot and immunohistochemistry.

1:50

Western blots performed on each lot.

Rabbit

Liquid

IgG

Human

Quality Control: WB

AB_3068506