Anti-SNPH Antibody Picoband® fluoro550 Vervoeging

Syntaphilin is a protein that in humans is encoded by the SNPH gene. Syntaxin-1, synaptobrevin/VAMP, and SNAP25 interact to form the SNARE complex, which is required for synaptic vesicle docking and fusion. The protein encoded by this gene is membrane-associated and inhibits SNARE complex formation by binding free syntaxin-1. Expression of this gene appears to be brain-specific. Alternative splicing results in multiple transcript variants encoding different isoforms.

Pannexin-2; PANX2

SNPH

9751

O15079

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human SNPH recombinant protein (Position: Y43-Q482) .

Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts.

Flow Cytometry

Organelles, Subcellular Markers, Tags & Cell Markers

Immunogen affinity purified.

Liquid

Structural component of the gap junctions and the hemichannels.

1. Lao, G., Scheuss, V., Gerwin, C. M., Su, Q., Mochida, S., Rettig, J., Sheng, Z.-H. Syntaphilin: a syntaxin-1 clamp that controls SNARE assembly. Neuron 25: 191-201, 2000. 2. Nagase, T., Ishikawa, K., Nakajima, D., Ohira, M., Seki, N., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 4: 141-150, 1997.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Pannexin 2

Cell membrane. Multi-pass membrane protein. Gap junction.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.