Anti-SNRNP27 Antibody Picoband® fluoro488 Vervoeging

This gene encodes a serine/arginine-rich (SR) protein. SR proteins play important roles in pre-mRNA splicing by facilitating the recognition and selection of splice sites. The encoded protein associates with the 25S U4/U6.U5 tri-snRNP, a major component of the U2-type spiceosome. The expression of this gene may be altered in cells infected with the human T-cell lymphotropic virus type 1 (HTLV-1) retrovirus. A pseudogene of this gene is located on the long arm of chromosome 5. Alternatively spliced transcript variants have been observed for this gene.

RNA-binding protein 47; RNA-binding motif protein 47; RBM47

SNRNP27

11017

Q8WVK2

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human SNRNP27 recombinant protein (Position: E100-A155) .

Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon. .

Flow Cytometry

Chromatin Binding Proteins, DNA/RNA Binding, Epigenetics and Nuclear Signaling

Immunogen affinity purified.

Liquid

Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.

1. Fetzer, S., Lauber, J., Will, C. L., Luhrmann, R. The [U4/U6.U5] tri-snRNP-specific 27K protein is a novel SR protein that can be phosphorylated by the snRNP-associated protein kinase. RNA 3: 344-355, 1997. 2. Gross, M. B. Personal Communication. Baltimore, Md. 11/18/2021. 3. Nakamura, Y., Moriuchi, R., Nakayama, D., Yamashita, I., HIgashiyama, Y., Yamamoto, T., Kusano, Y., Hino, S., Miyamoto, T., Katamine, S. Altered expression of a novel cellular gene as a consequence of integration of human T cell lymphotropic virus type 1. J. Gen. Virol. 75: 2625-2633, 1994.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

64099 MW

6

RNA-binding protein 47

Nucleus .

Follicular dendritic cell secreted peptide

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.