Anti-Somatostatine/SST Antilichaam Picoband® fluoro488 Vervoeging

SST (Somatostatin), also known as SMST, is a peptide hormone. Naylor et al. (1983) assigned the somatostatin gene to chromosome 3 by analyzing somatic cell hybrids with a polymorphic gene probe. Yacubova and Komuro (2002) examined the effects of somatostatin in cerebellar granule cells of early postnatal mice, because these cells express all 5 types of somatostatin receptors before the initiation of their migration. Saito et al. (2005) found that somatostatin modulated the proteolytic degradation of beta-amyloid catalyzed by neprilysin both in vitro and in vivo.

Somatostatin; Growth hormone release-inhibiting factor; Somatostatin-28; Somatostatin-14; SST

SST

6750

P61278

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human Somatostatin, identical to the related rat and mouse sequences.

Widely expressed at a high level in skeletal muscle and at a weak level in thymus. Expressed in epithelial dysplasias and squamous cell carcinoma. .

Flow Cytometry

DNA/RNA, DNA Damage & Repair, DNA Damage Response, Epigenetics and Nuclear Signaling, Metabolic Signaling Pathways, Metabolism, Nucleotide Metabolism, Oncoproteins/Suppressors, p53 Pathway, Pathways and Processes, Tumor Suppressors

Immunogen affinity purified.

Liquid

Somatostatin inhibits the release of somatotropin.

1. Naylor, S. L., Sakaguchi, A. Y., Shen, L.-P., Bell, G. I., Rutter, W. J., Shows, T. B. Polymorphic human somatostatin gene is located on chromosome 3. Proc. Nat. Acad. Sci. 80: 2686-2689, 1983. 2. Saito, T., Iwata, N., Tsubuki, S., Takaki, Y., Takano, J., Huang, S.-M., Suemoto, T., Higuchi, M., Saido, T. C. Somatostatin regulates brain amyloid beta-peptide A-beta-42 through modulation of proteolytic degradation. Nature Med. 11: 434-439, 2005. 3. Yacubova, E., Komuro, H. Stage-specific control of neuronal migration by somatostatin. Nature 415: 77-81, 2002.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

12736 MW

No cross reactivity with other proteins.

6

Somatostatin

Secreted.

Belongs to the somatostatin family.

Somatostatin

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.