Anti-SOX10 Antibody Picoband® 0,00647 Vervoeging

Transcription factor SOX-10 is a protein that in humans is encoded by the SOX10 gene. This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease.

Transcription factor SOX-10; SOX10

SOX10

6663

P56693

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human SOX10 recombinant protein (Position: R178-L301) .

Expressed in fetal brain and in adult brain, heart, small intestine and colon.

Flow Cytometry

Cell Type Marker, Developmental Biology, Domain Families, Epigenetics and Nuclear Signaling, Lineage Markers, Lineage Specification, Neuroscience, Stem Cells, Transcription

Immunogen affinity purified.

Liquid

Transcription factor that seems to function synergistically with the POU domain protein TST-1/OCT6/SCIP. Could confer cell specificity to the function of other transcription factors in developing and mature glia (By similarity) . .

1. Bondurand N, Kuhlbrodt K, Pingault V, Enderich J, Sajus M, Tommerup N, Warburg M, Hennekam RC, Read AP, Wegner M, Goossens M (Sep 1999) . A molecular analysis of the yemenite deaf-blind hypopigmentation syndrome: SOX10 dysfunction causes different neurocristopathies. Human Molecular Genetics. 8 (9) : 1785–9. 2. Huber WE, Price ER, Widlund HR, Du J, Davis IJ, Wegner M, Fisher DE (Nov 2003) . A tissue-restricted cAMP transcriptional response: SOX10 modulates alpha-melanocyte-stimulating hormone-triggered expression of microphthalmia-associated transcription factor in melanocytes. The Journal of Biological Chemistry.278 (46) : 45224–30.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

SRY-box 10

Cytoplasm. Nucleus.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.