Anti-SOX7 Antibody Picoband® fluoro488 Vervoeging

SOX7 belongs to SOX gene family and SOX proteins are transcription factors with critical roles in the regulation of diverse developmental processes. This gene is mapped to 8p23.1. SOX7 gene contains at least 2 exons. In cotransfected 293 cells, Sox7 reduced Wnt (see WNT1) /beta-catenin (see CTNNB1) - stimulated transcription. SOX7 is a potent activator of FGF3 transcription. It not only plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium but also blocks further differentiation into blood precursors. And it may be required for the survival of both hematopoietic and endothelial precursors during specification.

Transcription factor SOX-7; SOX7

SOX7

83595

Q9BT81

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human SOX7, identical to the related mouse and rat sequences.

Widely expressed in adult and fetal tissues. Present both in mesenchymal and epithelial cells in some adult tissues, including colon. Tends to be down-regulated in prostate adenocarcinomas and colorectal tumors due to promoter hypermethylation. .

Flow Cytometry

Developmental Biology, Developmental Families, Domain Families, Epigenetics and Nuclear Signaling, Lineage Markers, Lineage Specification, Stem Cells, Transcription

Immunogen affinity purified.

Liquid

Binds to and activates the CDH5 promoter, hence plays a role in the transcriptional regulation of genes expressed in the hemogenic endothelium and blocks further differentiation into blood precursors (By similarity) . May be required for the survival of both hematopoietic and endothelial precursors during specification (By similarity) . Competes with GATA4 for binding and activation of the FGF3 promoter (By similarity) . Represses Wnt/beta-catenin-stimulated transcription, probably by targeting CTNNB1 to proteasomal degradation. Binds the DNA sequence 5'- AACAAT-3'. .

1. Murakami, A., Shen, H., Ishida, S., Dickson, C. SOX7 and GATA-4 are competitive activators of Fgf-3 transcription. J. Biol. Chem. 279: 28564-28573, 2004. 2. Sox7 Is an independent checkpoint for beta-catenin function in prostate and colon epithelial cells. Guo L., Zhong D., Lau S., Liu X., Dong X.Y., Sun X., Yang V.W., Vertino P.M., Moreno C.S., Varma V., Dong J.T., Zhou W. Mol. Cancer Res. 6:1421-1430 (2008) . 3. Takash, W., Canizares, J., Bonneaud, N., Poulat, F., Mattei, M.-G., Jay, P., Berta, P. SOX7 transcription factor: sequence, chromosomal localisation, expression, transactivation and interference with Wnt signaling. Nucleic Acids Res. 29: 4274-4283, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

42197 MW

No cross reactivity with other proteins.

6

Transcription factor SOX-7

Nucleus . Cytoplasm .

Contains 1 HMG box DNA-binding domain.

Transcription factor SOX-7

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.