Anti-SPATA20 Antibody Picoband® fluoro488 Vervoeging

SPATA20 (Spermatogenesis Associated 20), located on human chromosome 17q21.33, is a member of thioredoxin family. The human SPATA20 gene, also known as SSP411, Tisp78 and HEL-S-98, encodes an 87899 Da protein containing 786 amino acids. The SPATA20 protein is broadly expressed in testis, thyroid and other tissues. The SPATA20 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, etc. 336 organisms have orthologs with human gene SPATA20. SPATA20 is associated with some diseases, including Common Bile Duct Disease and Choledocholithiasis.

Kelch repeat and BTB domain-containing protein 2; BTB and kelch domain-containing protein 1; KBTBD2; BKLHD1; KIAA1489

SPATA20

64847

Q8TB22

Human, Mouse

No cross-reactivity with other proteins.

E.coli-derived human SPATA20 recombinant protein (Position: K396-P786) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Hartz, P. A. Personal Communication. Baltimore, Md. 4/19/2011. 2. Shi, H.-J., Wu, A. Z., Santos, M., Feng, Z.-M., Huang, L., Chen, Y.-M., Zhu, K., Chen, C.-L. C. Cloning and characterization of rat spermatid protein SSP411: a thioredoxin-like protein. J. Androl. 25: 479-493, 2004.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

24145 MW

6

Kelch repeat and BTB domain containing 2

Cul3-RING ubiquitin ligase complex.

Transmembrane protein 240

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.