Anti-SRPRB Antibody Picoband® fluoro594 Vervoeging

Signal recognition particle receptor subunit beta is a protein that in humans is encoded by the SRPRB gene. The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR) . This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane.

RNA-binding protein 47; RNA-binding motif protein 47; RBM47

SRPRB

58477

Q9Y5M8

Human

No cross-reactivity with other proteins

E.coli-derived human SRPRB recombinant protein (Position: K55-A271) .

Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon. .

Flow Cytometry

Chromatin Binding Proteins, DNA/RNA Binding, Epigenetics and Nuclear Signaling

Immunogen affinity purified.

Liquid

Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.

1. Hartz, P. A. Personal Communication. Baltimore, Md. 3/28/2016. 2. Legate, K. R., Falcone, D., Andrews, D. W. Nucleotide-dependent binding of the GTPase domain of the signal recognition particle receptor beta-subunit to the alpha-subunit. J. Biol. Chem. 275: 27439-27446, 2000. 3. Miller, J. D., Tajima, S., Lauffer, L., Walter, P. The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane. J. Cell Biol. 128: 273-282, 1995.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

64099 MW

6

RNA-binding protein 47

Nucleus .

Follicular dendritic cell secreted peptide

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.