Anti-SSBP1 Antibody Picoband® fluoro594 Vervoeging

Single-stranded DNA-binding protein, mitochondrial is a protein that in humans is encoded by the SSBP1 gene. SSBP1 is a housekeeping gene involved in mitochondrial biogenesis. It is also a subunit of a single-stranded DNA (ssDNA) -binding complex involved in the maintenance of genome stability.

Protein Dok-7; Downstream of tyrosine kinase 7; DOK7; C4orf25

SSBP1

6742

Q04837

Human

No cross-reactivity with other proteins.

E.coli-derived human SSBP1 recombinant protein (Position: M1-E148) .

Preferentially expressed in skeletal muscle and heart. Present in thigh muscle, diaphragm and heart but not in the liver or spleen .

Flow Cytometry

Adapters, Protein Phosphorylation, Receptor Tyrosine Kinases, Signal Transduction, Transmembrane, Tyrosine Kinases

Immunogen affinity purified.

Liquid

Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromuscular synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK.

1. Bogenhagen, D. F., Rousseau, D., Burke, S. The layered structure of human mitochondrial DNA nucleoids. J. Biol. Chem. 283: 3665-3675, 2008. 2. Del Dotto, V., Ullah, F., Di Meo, I., Magini, P., Gusic, M., Maresca, A., Caporali, L., Palombo, F., Tagliavini, F., Baugh, E. H., Macao, B., Szilagyi, Z., and 35 others. SSBP1 mutations cause mtDNA depletion underlying a complex optic atrophy disorder. J. Clin. Invest. 130: 108-125, 2020. 3. Huang, J., Gong, Z., Ghosal, G., Chen, J. SOSS complexes participate in the maintenance of genomic stability. Molec. Cell 35: 384-393, 2009.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

67074 MW

6

Docking protein 7

Cell membrane, Peripheral membrane protein, Synapse.

Long-chain-fatty-acid--CoA ligase 5

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.