Anti-ST5 Antibody Picoband® fluoro594 Vervoeging

Suppression of tumorigenicity 5 is a protein that in humans is encoded by the ST5 gene. This gene is mapped to 11p15.4. The protein encoded by this gene contains a C-terminal region that shares similarity with the Rab 3 family of small GTP binding proteins. This protein preferentially binds to the SH3 domain of c-Abl kinase, and acts as a regulator of MAPK1/ERK2 kinase, which may contribute to its ability to reduce the tumorigenic phenotype in cells. Three alternatively spliced transcript variants of this gene encoding distinct isoforms are identified.

Suppression of tumorigenicity 5 protein; DENN domain-containing protein 2B; HeLa tumor suppression 1; ST5; DENND2B, HTS1

ST5

6764

P78524

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human ST5, different from the related mouse and rat sequences by one amino acid.

Widely expressed with the exception of peripheral blood lymphocytes. Isoform 1 is expressed in several epithelial and fibroblast (including tumorigenic) but absent in lymphoid cell lines (at protein level) . Isoform 3 is expressed in primary cell or weakly tumorigenic but not in tumorigenic cell lines (at protein level) . .

Flow Cytometry

Cancer, MAPK Pathway, Oncoproteins/Suppressors, Protein Phosphorylation, Ser/Thr Kinases, Signal Transduction, Tumor Suppressors

Immunogen affinity purified.

Liquid

Guanine nucleotide exchange factor (GEF) which may activate RAB9A and RAB9B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP- bound form. May be involved in cytoskeletal organization and tumorogenicity. Isoform 1 seems to be involved in a signaling transduction pathway leading to activation of MAPK1/ERK2. Isoform 3 may block ERK2 activation stimulated by ABL1. Isoform 3 may alter cell morphology and cell growth. .

1. Entrez Gene: ST5 suppression of tumorigenicity 5 2. Lichy JH, Modi WS, Seuanez HN, Howley PM (Nov 1992) . Identification of a human chromosome 11 gene which is differentially regulated in tumorigenic and nontumorigenic somatic cell hybrids of HeLa cells.Cell Growth Differ 3 (8) : 541–8. 3. Trautmann, U., Vikkula, M., Winterpacht, A., FitzPatrick, D. R., Rauch, A. Disruption of ST5 is associated with mental retardation and multiple congenital abnormalities. J. Med. Genet. 47: 91-98, 2010.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

126485 MW

No cross reactivity with other proteins.

6

Suppression of tumorigenicity 5 protein

Contains 1 dDENN domain.

Suppression of tumorigenicity 5 protein

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.