Anti-STAT2 Konijn Monoklonale Antilichaam

Boster Bio Anti-STAT2 Rabbit Monoclonal Antibody catalog # M01360. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human, Mouse, Rat.

Signal transducer and activator of transcription 2; p113; STAT2

STAT2

6773

P52630

Human, Mouse, Rat

A synthesized peptide derived from human STAT2

Clone: HCB-19

Expressed in endoderm, intestinal epithelial cells and in most extraembryonic tissues. .

WB, IHC, ICC, IF

Epigenetics and Nuclear Signaling, Nuclear Signaling, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway, Transcription

Affinity-chromatography

0.5mg/ml

Liquid

Signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta) . Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M01360

97916 MW

48 kDa

Signal transducer and activator of transcription 2

Cytoplasm. Nucleus. Translocated into the nucleus upon activation by IFN-alpha/beta.

Glycogen synthase kinase-3 beta (gsk3b)

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.