Anti-STAT4 Antibody Picoband® 0,00647 Vervoeging

STAT4 is a human gene. The protein encoded by this gene is a member of the STAT protein family of transcription factors. STAT4 is mapped to chromosome 2q32.2-q32.3 by fluorescence in situ hybridization. STAT4 is phosphorylated in response to interleukin-12 and is essential for IL12 signal transduction. Transactivation, electrophoretic mobility shift, and RNA interference analyses showed that Ikaros bound to the STAT4 promoter and was involved in regulation of STAT4 in human T cells.

Signal transducer and activator of transcription 4; STAT4

STAT4

6775

Q14765

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human STAT4, identical to the related rat and mouse sequences.

Flow Cytometry

Cancer, Epigenetics and Nuclear Signaling, Nuclear Signaling, Nuclear Signaling Pathways, Signal Transduction, Signaling Pathway, Transcription

Immunogen affinity purified.

Liquid

Carries out a dual function: signal transduction and activation of transcription. Involved in IL12 signaling.

1. Frucht, D. M., Aringer, M., Galon, J., Danning, C., Brown, M., Fan, S., Centola, M., Wu, C.-Y., Yamada, N., Gabalaway, H. E., O'Shea, J. J.Stat4 is expressed in activated peripheral blood monocytes, dendritic cells, and macrophages at sites of Th1-mediated inflammation.J. Immun. 164: 4659-4664, 2000. 2. Pang, Y. H., Zheng, C. Q., Yang, X. Z., Zhang, W. J.Increased expression and activation of IL-12-induced Stat4 signaling in the mucosa of ulcerative colitis patients.Cell. Immunol. 248: 115-120, 2007. 3. Yap, W.-H., Yeoh, E., Tay, A., Brenner, S., Venkatesh, B.STAT4 is a target of the hematopoietic zinc-finger transcription factor Ikaros in T cells.FEBS Lett. 579: 4470-4478, 2005.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

86 kDa

No cross reactivity with other proteins.

6

Signal transducer and activator of transcription 4

Cytoplasm. Nucleus. Translocated into the nucleus in response to phosphorylation.

Belongs to the transcription factor STAT family.

Signal transducer and activator of transcription 4

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.