Anti-STAT5b Antibody Picoband® 0,00647 Vervoeging

STAT5B (Signal transducer and activator of transcription 5B) is a protein that in humans is encoded by the STAT5B gene. STAT5B orthologs have been identified in most placentals for which complete genome data are available. By FISH, Lin et al. (1996) mapped STAT5B to 17q11.2. The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APML) . The dysregulation of the signaling pathways mediated by this protein may be the cause of the APML.

Signal transducer and activator of transcription 5B; STAT5B

STAT5B

6777

P51692

Rat, Mouse, Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human STAT5b, identical to the related rat and mouse sequences.

Widely expressed. .

Flow Cytometry

Cancer, Cancer Metabolism, Epigenetics and Nuclear Signaling, Metabolism, Metabolism Processes, Nuclear Signaling, Nuclear Signaling Pathways, Pathways and Processes, Response To Hypoxia, Signal Transduction, Signaling Pathway, Transcription

Immunogen affinity purified.

Liquid

Carries out a dual function: signal transduction and activation of transcription. Mediates cellular responses to the cytokine KITLG/SCF and other growth factors. Binds to the GAS element and activates PRL-induced transcription. .

1. Ambrosio, R., Fimiani, G., Monfregola, J., Sanzari, E., De Felice, N., Salerno, M. C., Pignata, C., D'Urso, M., Ursini, M. V.The structure of human STAT5A and STAT5B genes reveals two regions of nearly identical sequence and an alternative tissue specific STAT5B promoter.Gene 285: 311-318, 2002. 2. Arnould, C., Philippe, C., Bourdon, V., Gregoire, M. J., Berger, R., Jonveaux, P.The signal transducer and activator of transcription STAT5b gene is a new partner of retinoic acid receptor alpha in acute promyelocytic-like leukaemia.Hum. Molec. Genet. 8: 1741-1749, 1999. 3. Lin, J.-X., Mietz, J., Modi, W. S., John, S., Leonard, W. J.Cloning of human Stat5B: reconstitution of interleukin-2-induced Stat5A and Stat5B DNA binding activity in COS-7 cells.J. Biol. Chem. 271: 10738-10744, 1996.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

89866 MW

No cross reactivity with other proteins.

6

Signal transducer and activator of transcription 5B

Cytoplasm . Nucleus . Translocated into the nucleus in response to phosphorylation. .

Belongs to the transcription factor STAT family.

Signal transducer and activator of transcription 5B

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.