Anti-STEA2 Antilichaam (Center)

This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Boster Bio Anti-STEA2 Antibody (Center) (Catalog # A08410-2) . Tested in WB, Flow Cytometry, IHC-P application (s) . This antibody reacts with Human, Mouse.

Metalloreductase STEAP2, 1161-, Prostate cancer-associated protein 1, Protein up-regulated in metastatic prostate cancer, PUMPCn, Six-transmembrane epithelial antigen of prostate 2, SixTransMembrane protein of prostate 1, STEAP2, PCANAP1, STAMP1

STEAP2

Q8NFT2

Human, Mouse

This STEAP2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 229-258 amino acids of human STEAP2.

Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.

WB, Flow Cytometry, IHC-P

Cancer

This antibody is purified through a protein A column, followed by peptide affinity purification.

Integral membrane protein that functions as NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe (3+) chelate that is bound on the other side of the membrane (By similarity) . Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe (3+) chelate (By similarity) . Can also reduce Cu (2+) to Cu (1+) (By similarity) .

Maintain refrigerated at 2-8°C for up to 2 weeks. For long-term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=A08410-2

56056 Da

Endosome membrane {ECO:0000250|UniProtKB:Q8BWB6}; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein

Rabbit IgG

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.