Anti-Stra8 Antibody Picoband® 0,00647 Vervoeging

Stra8, stimulated by retinoic acid 8, is expressed in embryonic ovaries just before meiotic initiation, whereas in testis it is expressed after birth. The STRA8 gene contains 9 exons. And this gene is mapped to chromosome 7q31. Retinoic acid (RA) signaling was required for Stra8 expression, and therefore initiation of meiosis, in embryonic mouse ovaries. RA was sufficient to induce Stra8 expression in embryonic testis. Cyp26-mediated RA metabolism was responsible for delaying Stra8 expression in embryonic testis. Since RA signaling regulated Stra8 expression in both embryonic ovaries and adult testis, it was said this portion of the meiotic initiation pathway may be identical in both sexes.

Stimulated by retinoic acid gene 8 protein homolog; STRA8

STRA8

346673

Q7Z7C7

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human Stra8.

Expressed specifically in testis. .

Flow Cytometry

Developmental Biology, Embryogenesis, Embryonic Stem Cells, Germ Cell Markers, Germline Stem Cells, Intracellular, Reproduction, Stem Cells, Surface Molecules

Immunogen affinity purified.

Liquid

Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, required for premeiotic DNA replication and subsequent events in meiotic prophase (By similarity) . .

1. Anderson, E. L., Baltus, A. E., Roepers-Gajadien, H. L., Hassold, T. J., de Rooij, D. G., van Pelt, A. M. M., Page, D. C.Stra8 and its inducer, retinoic acid, regulate meiotic initiation in both spermatogenesis and oogenesis in mice.Proc. Nat. Acad. Sci. 105: 14976-14980, 2008. 2. Miyamoto, T., Sengoku, K., Takuma, N., Hasuike, S., Hayashi, H., Yamauchi, T., Yamashita, T., Ishikawa, M.Isolation and expression analysis of the testis-specific gene, STRA8, stimulated by retinoic acid gene 8.J. Assisted Reprod. Genet. 19: 531-535, 2002.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

36908 MW

No cross reactivity with other proteins.

6

Stimulated by retinoic acid gene 8 protein homolog

Cytoplasm .

Belongs to the G-protein coupled receptor 1 family.

Stimulated by retinoic acid gene 8 protein homolog

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.