Anti-Stromelysin-2 MMP10 Antibody Picoband® Fluroc47 Vervoeging

Stromelysin-2 also known as matrix metalloproteinase-10 (MMP-10) or transin-2 is an enzyme that in humans is encoded by the MMP10 gene.Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The enzyme encoded by this gene degrades proteoglycans and fibronectin. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.

Stromelysin-2; SL-2;3.4.24.22; Matrix metalloproteinase-10; MMP-10; Transin-2; MMP10; STMY2

MMP10

4319

P09238

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human MMP10.

Flow Cytometry

Angiogenesis, Cancer, Cardiovascular, Cell Biology, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes

Immunogen affinity purified.

Liquid

Can degrade fibronectin, gelatins of type I, III, IV, and V; weakly collagens III, IV, and V. Activates procollagenase.

1. Muller D, Quantin B, Gesnel MC, Millon-Collard R, Abecassis J, Breathnach R (July 1988) . The collagenase gene family in humans consists of at least four members. Biochem. J. 253 (1) : 187–92. 2. Jung JY, Warter S, Rumpler Y (1990) . Localization of stromelysin 2 gene to the q22.3-23 region of chromosome 11 by in situ hybridization. Ann. Genet. 33 (1) : 21–3.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

54151 MW

No cross reactivity with other proteins.

6

Stromelysin-2

Secreted, extracellular space, extracellular matrix .

Belongs to the peptidase M10A family.

Stromelysin-2 (SL-2)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.