Anti-Sts-1 UBASH3B Antilichaam

Sts-1 is a protein that inhibits endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. Sts-1 and Sts-2 (formerly p70 and Clip4, respectively) have been found to interact with Cbl, an ubiquitin ligase that plays a critical role in attenuation of receptor tyrosine kinase signaling by inducing ubiquitination and promoting their sorting for endosomal degradation. Sts-1 and Sts-2 contain SH3 domains that interact with Cbl, Ub-associated domains, which bind directly to mono-Ub or to the EGFR/Ub chimera, as well as phosphoglycerate mutase domains that mediate oligomerization of Sts-1/2. Sts-1 and Sts-2 also have been found to negatively regulate signaling pathways that control T cell receptors, which in turn affect the extent and duration of the T cell response to foreign pathogens.

Boster Bio Anti-Sts-1 UBASH3B Antibody (Catalog # A09570) . Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse.

Sts-1, Sts1, Sts 1, Ubiquitin-associated and SH3 domain-containing protein B, Cbl interacting protein p70, Suppressor of T-cell receptor signaling 1, T-cell ubiquitin ligand 2, TULA-2, Tyrosine-protein phosphatase STS1/TULA2, Ubash3B

UBASH3B

Q8TF42

Human, Mouse

This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the C-terminus of mouse Sts-1.

ELISA, IHC, IF, WB

Adapters, Adaptive Immunity, Cell Biology, Immunology, Proteasome / Ubiquitin, Protein Trafficking, Proteolysis/Ubiquitin, Signal Transduction, T Cells, Vesicle Transport

This affinity purified antibody is directed against mouse Sts-1 protein. The product was affinity purified from monospecific antiserum by immunoaffinity purification. A BLAST analysis was used to suggest reactivity with this protein from mouse, human, rat and dog based on 100% homology for the immunogen sequence. Cross-reactivity with Sts-1 homologues from other sources has not been determined.

0.95 mg/mL by UV absorbance at 280 nm

Liquid (sterile filtered)

Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.

Dry Ice Shipping

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.

https://www.bosterbio.com/msds?sku=A09570

72696 MW

Ubiquitin-associated and SH3 domain-containing protein B

Cytoplasm. Nucleus.

IgG

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01% (w/v) Sodium Azide