Anti-SUMF2 Antibody Picoband® 31.0550 Vervoeging

Sulfatase-modifying factor 2 is an enzyme that in humans is encoded by the SUMF2 gene. The catalytic sites of sulfatases are only active if they contain a unique amino acid, C-alpha-formylglycine (FGly) . The FGly residue is posttranslationally generated from a cysteine by enzymes with FGly-generating activity. The gene described in this record is a member of the sulfatase-modifying factor family and encodes a protein with a DUF323 domain that localizes to the lumen of the endoplasmic reticulum. This protein has low levels of FGly-generating activity but can heterodimerize with another family member - a protein with high levels of FGly-generating activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Pannexin-2; PANX2

SUMF2

25870

Q8NBJ7

Human

No cross-reactivity with other proteins.

E.coli-derived human SUMF2 recombinant protein (Position: Q26-L301) .

Expressed in fetal and adult brain. Also detected in fetal liver and skeletal muscle, but not in their adult counterparts.

Flow Cytometry

Organelles, Subcellular Markers, Tags & Cell Markers

Immunogen affinity purified.

Liquid

Structural component of the gap junctions and the hemichannels.

1. Cosma, M. P., Pepe, S., Annunziata, I., Newbold, R. F., Grompe, M., Parenti, G., Ballabio, A. The multiple sulfatase deficiency gene encodes an essential and limiting factor for the activity of sulfatases. Cell 113: 445-456, 2003. 2. Dierks, T., Schmidt, B., Borissenko, L. V., Peng, J., Preusser, A., Mariappan, M., von Figura, K. Multiple sulfatase deficiency is caused by mutations in the gene encoding the human C-alpha-formylglycine generating enzyme. Cell 113: 435-444, 2003. 3. Gross, M. B. Personal Communication. Baltimore, Md. 2/26/2015.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Pannexin 2

Cell membrane. Multi-pass membrane protein. Gap junction.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.