Anti-Sumo 1 Konijn Monoklonale Antilichaam

Boster Bio Anti-Sumo 1 Rabbit Monoclonal Antibody catalog # M00631-1. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Small ubiquitin-related modifier 1; SUMO-1; GAP-modifying protein 1; GMP1; SMT3 homolog 3; Sentrin; Ubiquitin-homology domain protein PIC1; Ubiquitin-like protein SMT3C; Smt3C; Ubiquitin-like protein UBL1; SUMO1; SMT3C, SMT3H3, UBL1; OK/SW-cl.43

SUMO1

7341

P63165

Human, Mouse, Rat

A synthesized peptide derived from human Sumo 1

Clone: BFI-19

Fetal muscle and adult liver, brain and thyroid.

WB, IHC, ICC, IF, IP, Flow Cytometry

Cancer, Cardiovascular, Cell Biology, Cell Death, Metabolism, Metabolism Processes, Pathways and Processes, Proteasome / Ubiquitin, Proteolysis/Ubiquitin

Affinity-chromatography

0.5mg/ml

Liquid

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Covalently attached to the voltage-gated potassium channel KCNB1; this modulates the gating characteristics of KCNB1 (PubMed:19223394) . Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M00631-1

11557 MW

26 kDa

Small ubiquitin-related modifier 1

Nucleus membrane. Nucleus speckle. Cytoplasm. Nucleus, PML body. Cell membrane . Recruited by BCL11A into the nuclear body. .

T-cell surface glycoprotein CD4

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.