Anti-superoxide dismutase 1 (SOD1) Antilichaam

FUNCTION: Destroys radicals which are normally produced within the cells and which are toxic to biological systems. CATALYTIC ACTIVITY: 2 superoxide + 2 H+ = O2 + H2O2. COFACTOR: Binds 1 copper ion per subunit. COFACTOR: Binds 1 zinc ion per subunit. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. DISEASE: Defects in SOD1 are the cause of familial amyotrophic lateral sclerosis (FALS) ; also called amyotrophic lateral sclerosis 1 (ALS1 or ALS) . ALS is a degenerative disorder of motorneurons in the cortex, brainstem and spinal cord. ALS is characterized by muscular weakness and atrophy beginning in the hands and spreading to the forearms and legs. Muscle fasciculations are commonly visible. Sensory abnormalities are absent. Death usually occurs within 2 to 5 years. ALS is sometimes referred to as Lou Gehrig disease after the famous American baseball player who was diagnosed with the disorder. FALS, the familial form of ALS, accounts for about 10% of the cases and is transmitted in an autosomal dominant manner. The mean age at onset of FALS is 45 years. MISCELLANEOUS: Zinc binding promotes dimerization. SIMILARITY: Belongs to the Cu-Zn superoxide dismutase family.

Our Anti-Superoxide dismutase 1 (SOD1) rabbit polyclonal primary antibody detects mouse and rat Superoxide dismutase 1 (SOD1), and is whole serum. It is validated for use in WB.

Our Anti-Superoxide dismutase 1 (SOD1) rabbit polyclonal primary antibody detects mouse and rat Superoxide dismutase 1 (SOD1), and is whole serum. It is validated for use in WB.

Superoxide dismutase [Cu-Zn]; SOD1

P08228

Mouse and Rat

A synthetic peptide (ASGEPVV LSGQIT) as part of mouse superoxide dismutase (SOD1) protein (aa: 24-36) conjugated to diphtheria toxoid

Superoxide dismutase 1 (SOD1)

Unconjugated

WB

Whole serum

For research use only.

25°C (ambient)

Spin vial briefly before opening. Reconstitute in 100 μL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Glycerol (1:1) may be added for an additional stability. Avoid repetitive freeze/thaw cycles.

1:500-1:1000

Specificity was confirmed by Western blot detecting mouse superoxide dismutase (SOD1) . This antiserum is known to react with mouse and rat superoxide dismutase (SOD1) protein.

Rabbit

Lyophilized

Mixed

Mouse