Anti-Superoxide Dismutase 1/SOD1 Antibody Picoband® fluoro488 Vervoeging

Superoxide dismutases (SOD) are a class of enzymes that catalyze the dismutation of superoxide into oxygen and hydrogen peroxide. As such, they are an important antioxidant defense in nearly all cells exposed to oxygen. One of the exceedingly rare exceptions is Lactobacillus plantarum and related lactobacilli, which use a different mechanism.Cu, Zn-SOD was found widely distributed in the cell cytosol and in the cell nucleus, consistent with it being a soluble cytosolic protein. Mitochondria and secretory compartments did not label for this protein. In human cells, peroxisomes showed a labeling density slightly less than that of cytoplasm.

Superoxide dismutase [Cu-Zn];1.15.1.1; Superoxide dismutase 1; hSod1; SOD1

SOD1

6647

P00441

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of Human SOD1, different from the mouse sequence by two amino acids.

Expressed in neurons of the rolandic area of the brain (at protein level) . Expressed in the brain.

Flow Cytometry

Cancer, Cancer Metabolism, Cell Biology, Chaperones, Heat Shock Proteins, Metabolism, Oxidative Stress, Pathways and Processes, Protein Trafficking, Redox Metabolism, Signal Transduction

Immunogen affinity purified.

Liquid

Destroys radicals which are normally produced within the cells and which are toxic to biological systems.

1. Crapo, J. D., Oury, T., Rabouille, C., Slot, J. W., Chang, L.-Y. Copper, zinc superoxide dismutase is primarily a cytosolic protein in human cells. Proc. Nat. Acad. Sci. 89: 10405-10409, 1992.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

15936 MW

No cross reactivity with other proteins.

6

Superoxide dismutase [Cu-Zn]

Cytoplasm. Nucleus. Predominantly cytoplasmic; the pathogenic variants ALS1 Arg-86 and Ala-94 gradually aggregates and accumulates in mitochondria.

Belongs to the Cu-Zn superoxide dismutase family.

Superoxide dismutase[Cu-Zn]

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.