Anti-SURF2 Antibody Picoband® 31.0550 Vervoeging

SURF2 is a protein which in humans is encoded by the SURF2 gene. Surfeit 2, also known as SURF2, belongs to the SURF2 family and interacts with beta-1, 4-Gal-T3, uPAR and WDR20. SURF2 is located in the surfeit gene cluster, which is a group of very tightly linked genes that do not share sequence similarity. The SURF2 gene maps to human chromosome 9q34.2 and shares a biional promoter with SURF1, which is located on the opposite strand. The intergenic region between the SURF1 and SURF2 genes is expected to have biional promoter activity, as is found in mouse. Recombinant human SURF2 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

DAP3-binding cell death enhancer 1; Death ligand signal enhancer; DELE1; DELE; KIAA0141

SURF2

6835

Q15527

Human

No cross-reactivity with other proteins.

E.coli-derived human SURF2 recombinant protein (Position: D7-K230) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Signal Transduction

Immunogen affinity purified.

Liquid

Essential for the induction of death receptor-mediated apoptosis through the regulation of caspase activation.

1. Duhig, T., Ruhrberg, C., Mor, O., Fried, M. The human surfeit locus. Genomics 52: 72-78, 1998. 2. Lennard, A., Gaston, K., Fried, M. The Surf-1 and Surf-2 genes and their essential biional promoter elements are conserved between mouse and human. DNA Cell Biol. 13: 1117-1126, 1994. 3. Yon, J., Jones, T., Garson, K., Sheer, D., Fried, M. The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1. Hum. Molec. Genet. 2: 237-240, 1993.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

64099 MW

6

DAP3 binding cell death enhancer 1

Mitochondrion.

DAP3 binding cell death enhancer 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.