Anti-SV2C Antibody Picoband® 31.0550 Vervoeging

Predicted to enable transmembrane transporter activity. Predicted to be involved in several processes, including chemical synaptic transmission; neurotransmitter transport; and regulation of synaptic vesicle exocytosis. Predicted to be located in plasma membrane and synaptic vesicle. Predicted to be active in dopaminergic synapse and synaptic vesicle membrane.

SV2C; KIAA1054; Synaptic vesicle glycoprotein 2C

SV2C

22987

Q496J9

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human SV2C recombinant protein (Position: M1-A579) . Human SV2C shares 96.7% and 96.5% amino acid (aa) sequence identity with mouse and rat SV2C, respectively.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Benoit, R. M., Frey, D., Hilbert, M., Kevenaar, J. T., Wieser, M. M., Stirnimann, C. U., McMillan, D., Ceska, T., Lebon, F., Jaussi, R., Steinmetz, M. O., Schertler, G. F. X., Hoogenraad, C. C., Capitani, G., Kammerer, R. A. Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A. Nature 505: 108-111, 2014. 2. Dong, M., Yeh, F., Tepp, W. H., Dean, C., Johnson, E. A., Janz, R., Chapman, E. R. SV2 is the protein receptor for botulinum neurotoxin A. Science 312: 592-596, 2006. 3. Iezzi, M., Theander, S., Janz, R., Loze, C., Wollheim, C. B. SV2A and SV2C are not vesicular Ca (2+) transporters but control glucose-evoked granule recruitment. J. Cell Sci. 118: 5647-5660, 2005.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

82 kDa

6

Synaptic vesicle glycoprotein 2C

Synaptic vesicle glycoprotein 2C

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.