Anti-SWAN/RBM12 Antibody Picoband® fluoro647 Vervoeging

RNA-binding protein 12 is a protein that in humans is encoded by the RBM12 gene. This gene encodes a protein that contains several RNA-binding motifs, potential transmembrane domains, and proline-rich regions. This gene and the gene for copine I overlap at map location 20q11.21. Alternative splicing in the 5' UTR results in four transcript variants. All variants encode the same protein.

RNA-binding protein 47; RNA-binding motif protein 47; RBM47

RBM12

10137

Q9NTZ6

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human SWAN/RBM12 recombinant protein (Position: Q287-E909) .

Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon. .

Flow Cytometry

Chromatin Binding Proteins, DNA/RNA Binding, Epigenetics and Nuclear Signaling

Immunogen affinity purified.

Liquid

Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.

1. Nagase, T., Ishikawa, K., Suyama, M., Kikuno, R., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 5: 277-286, 1998. 2. Steinberg, S., Gudmundsdottir, S., Sveinbjornsson, G., Suvisaari, J., Paunio, T., Torniainen-Holm, M., Frigge, M. L., Jonsdottir, G. A., Huttenlocher, J., Arnarsdottir, S., Ingimarsson, O., Haraldsson, M., Tyrfingsson, T., Thorgeirsson, T. E., Kong, A., Norddahl, G. L., Gudbjartsson, D. F., Sigurdsson, E., Stefansson, H., Stefansson, K. Truncating mutations in RMB12 are associated with psychosis. Nature Genet. 49: 1251-1254, 2017. 3. Stover, C., Gradl, G., Jentsch, I., Speicher, M. R., Wieser, R., Schwaeble, W. cDNA cloning, chromosome assignment, and genomic structure of a human gene encoding a novel member of the RBM family. Cytogenet. Cell Genet. 92: 225-230, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

64099 MW

6

RNA-binding protein 47

Nucleus .

Follicular dendritic cell secreted peptide

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.