Anti-Synaptogyrine 3/SYNGR3 Antibody Picoband® fluoro488 Vervoeging

Synaptogyrin 3 is a protein that in humans is encoded by the SYNGR3 gene. This gene encodes an integral membrane protein. The exact function of this protein is unclear, but studies of a similar murine protein suggest that it is a synaptic vesicle protein that also interacts with the dopamine transporter. The gene product belongs to the synaptogyrin gene family.

Transmembrane protein 199; TMEM199; C17orf32

SYNGR3

9143

O43761

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human Synaptogyrin 3/SYNGR3 recombinant protein (Position: N45-Y229) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Accessory component of the proton-transporting vacuolar (V) -ATPase protein pump involved in intracellular iron homeostasis. In aerobic conditions, required for intracellular iron homeostasis, thus triggering the activity of Fe2+ prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation. Necessary for endolysosomal acidification and lysosomal degradation. May be involved in Golgi homeostasis.

1. Kedra, D., Pan, H.-Q., Seroussi, E., Fransson, I., Guilbaud, C., Collins, J. E., Dunham, I., Blennow, E., Roe, B. A., Piehl, F., Dumanski, J. P. Characterization of the human synaptogyrin gene family. Hum. Genet. 103: 131-141, 1998.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

64099 MW

6

Transmembrane protein 199

Endoplasmic reticulum membrane. Multi-pass membrane protein. COPI-coated vesicle membrane. Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane. Multi-pass membrane protein.

DAP3 binding cell death enhancer 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.