Anti-Synaptotagmin-12/SYT12 Antibody Picoband® Biotin Conjugated

This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. Studies of the orthologous gene in rat have shown that the encoded protein selectively modulates spontaneous synaptic-vesicle exocytosis and may also be involved in regulating calcium independent secretion in nonneuronal cells. Alternative splicing results in multiple transcript variants. The gene has previously been referred to as synaptotagmin XI but has been renamed synaptotagmin XII to be standard with mouse and rat official nomenclature.

SYT12; Synaptotagmin-12; Synaptotagmin XII; SytXII

SYT12

91683

Q8IV01

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human Synaptotagmin-12/SYT12 recombinant protein (Position: Q63-R410) . Human Synaptotagmin-12/SYT12 shares 94.5% and 95.7% amino acid (aa) sequence identity with mouse and rat Synaptotagmin-12/SYT12, respectively.

WB, IHC, ELISA

Immunogen affinity purified.

Liquid

1. Craxton, M. Genomic analysis of synaptotagmin genes. Genomics 77: 43-49, 2001. 2. Fernandez-Chacon, R., Konigstorfer, A., Gerber, S. H., Garcia, J., Matos, M. F., Stevens, C. F., Brose, N., Rizo, J., Rosenmund, C., Sudhof, T. C. Synaptotagmin I functions as a calcium regulator of release probability. Nature 410: 41-49, 2001. 3. Itoh, Y., Esaki, T., Kaneshige, M., Suzuki, H., Cook, M., Sokoloff, L., Cheng, S.-Y., Nunez, J. Brain glucose utilization in mice with a targeted mutation in the thyroid hormone alpha or beta receptor gene. Proc. Nat. Acad. Sci. 98: 9913-9918, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.

47 kDa

Synaptotagmin 12

Synaptotagmin-12

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.