Anti-Syntaffiline SNPH Antilichaam

Syntaphilin was initially identified in a yeast two-hybrid screen with the carboxy terminal region of Syntaxin-1 as bait. Syntaxin-1 is a key component of the synaptic vesicle docking machinery that forms the SNARE complex with synaptobrevin and SNAP-25. Syntaphilin competes with SNAP-25 for binding to syntaxin-1 and inhibits the formation of the SNARE complex, thereby potentially regulating synaptic vesicle exocytosis. Syntaphilin also binds dynamin-1 and inhibits dynamin-dependent endocytosis. Mice lacking syntaphilin show an increased level of mitochondrial motility and a reduced density of axonal mitochondria. This correlates with an enhanced short-term facilitation and significant impairments in motor ability, suggesting syntaphilin plays a major role in presynaptic function. Multiple isoforms are known to exist.

Boster Bio Anti-Syntaphilin SNPH Antibody (Catalog # A08882) . Tested in ELISA, WB, IHC-P, IF applications. This antibody reacts with Human, Mouse, Rat.

BA314N13.5, KIAA0374, Syntaphilin

SNPH

O15079

Human, Mouse, Rat

Syntaphilin antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human Syntaphilin. The immunogen is located within amino acids 80 - 130 of Syntaphilin.

Brain specific. Found in synapses.

ELISA, WB, IHC-P, IF

Neuroscience

Syntaphilin Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Inhibits SNARE complex formation by absorbing free syntaxin-1.

Syntaphilin antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

https://www.bosterbio.com/msds?sku=A08882

53537 MW

Syntaphilin

Membrane ; Single-pass membrane protein . Cell junction, synapse, synaptosome.

Syntaphilin

IgG

Syntaphilin Antibody is supplied in PBS containing 0.02% sodium azide.