Anti-TAB3 Antibody Picoband® 0,00647 Vervoeging

The product of this gene functions in the NF-kappaB signal transduction pathway. The encoded protein, and the similar and functionally redundant protein MAP3K7IP2/TAB2, forms a ternary complex with the protein kinase MAP3K7/TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent MAP3K7/TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. The human genome contains a related pseudogene. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Matrix metalloproteinase-16; MMP-16; 3.4.24.-; MMP-X2; Membrane-type matrix metalloproteinase 3; MT-MMP 3; MTMMP3; Membrane-type-3 matrix metalloproteinase; MT3-MMP; MT3MMP; MMP16; MMPX2

TAB3

257397

Q8N5C8

Human

No cross-reactivity with other proteins.

E.coli-derived human TAB3 recombinant protein (Position: R70-D656) .

Expressed in heart, brain, placenta, ovary and small intestine. Isoform Short is found in the ovary.

Flow Cytometry

Angiogenesis, Cancer, Cardiovascular, Cell Biology, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Metalloprotease, Proteolysis/Ubiquitin, Proteolytic Enzymes

Immunogen affinity purified.

Liquid

Endopeptidase that degrades various components of the extracellular matrix, such as collagen type III and fibronectin. Activates progelatinase A. Involved in the matrix remodeling of blood vessels. Isoform short cleaves fibronectin and also collagen type III, but at lower rate. It has no effect on type I, II, IV and V collagen. However, upon interaction with CSPG4, it may be involved in degradation and invasion of type I collagen by melanoma cells.

1. Jin, G., Klika, A., Callahan, M., Faga, B., Danzig, J., Jiang, Z., Li, X., Stark, G. R., Harrington, J., Sherf, B. Identification of a human NF-kappa-B-activating protein, TAB3. Proc. Nat. Acad. Sci. 101: 2029-2033, 2004. 2. Zhang, L., Ding, X., Cui, J., Xu, H., Chen, J., Gong, Y.-N., Hu, L., Zhou, Y., Ge, J., Lu, Q., Liu, L., Chen, S., Shao, F. Cysteine methylation disrupts ubiquitin-chain sensing in NF-kappa-B activation. Nature 481: 204-208, 2012.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

39125 MW

6

Matrix metallopeptidase 16

Isoform Long: Cell membrane ; Localized at the cell surface of melanoma cells.

RNA-binding protein Musashi homolog 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.