Anti-TAL1 Antibody Picoband® fluoro488 Vervoeging

T-cell acute lymphocytic leukemia protein 1 is a protein that in humans is encoded by the TAL1 gene. The protein encoded by TAL1 is a basic helix-loop-helix transcription factor. TAL1 is a transcriptionally complex gene that is expressed throughout development, activating or repressing transcription in hematopoietic, neural, and endothelial precursors. This gene is mapped to chromosome 1p33.

T-cell acute lymphocytic leukemia protein 1; TAL-1; Class A basic helix-loop-helix protein 17; bHLHa17; Stem cell protein; T-cell leukemia/lymphoma protein 5; TAL1; BHLHA17; SCL; TCL5

TAL1

6886

P17542

Human, Mouse, Rat

No cross-reactivity with other proteins.

A synthetic peptide corresponding to a sequence at the C-terminus of human TAL1, which shares 82.4% amino acid (aa) sequence identity with mouse and rat TAL1.

Leukemic stem cell.

Flow Cytometry

Cell Differentiation, Developmental Biology, Epigenetics and Nuclear Signaling, Hematopoietic Progenitors, Organogenesis, Stem Cells

Immunogen affinity purified.

Liquid

Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity) .

1. Hosur, V., Cox, M. L., Burzenski, L. M., Riding, R. L., Alley, L., Lyons, B. L., Kavirayani, A., Martin, K. A., Cox, G. A., Johnson, K. R., Shultz, L. D. Retrotransposon insertion in the T-cell acute lymphocytic leukemia 1 (Tal1) gene is associated with severe renal disease and patchy alopecia in hairpatches (Hpt) mice. PLoS One 8: e53426, 2013. Note: Electronic Article. 2. Hu, X., Li, X., Valverde, K., Fu, X., Noguchi, C., Qiu, Y., Huang, S. LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis. Proc. Nat. Acad. Sci. 106: 10141-10146, 2009.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

50408 MW

6

TAL bHLH transcription factor 1, erythroid differentiation factor

Nucleus.

Protein C-ets-1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.