Anti-Tamaline GRASSP Antilichaam

This antibody is suitable for Cancer, Immunology and Nuclear Signaling research. Tamalin, also named General receptor for phosphoinositides 1-associated scaffold protein (GRASP) is a PDZ (post-synaptic density protein/Drosophila disc large tumor suppressor/zo-1) domain-containing protein that interacts with group 1 metabotropic glutamate receptors (mGluRs) . The PDZ domain-containing amino-terminal half of Tamalin binds directly to the class I PDZ-binding motif of group 1 mGluRs. The carboxyl-terminal half of Tamalin binds to cytohesins, which are guanine nucleotide exchange factors (GEFs) specific for the ADP-ribosylation factor (ARF) family of small GTP-binding proteins. Tamalin forms a protein complex with group 1 mGluRs at the post-synaptic site of specific neuronal cells and serves as a key scaffold protein that links a complex formation between mGluR1a and cytohesins. It is reported that Tamalin plays a key role in the association of group 1 mGluRs with the ARF-specific GEF proteins and contributes to intracellular trafficking and the macromolecular organization of group 1 mGluRs at synapses.

Boster Bio Anti-Tamalin GRASP Antibody (Catalog # A11078) . Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

Tamalin, Grasp, GRASP 1, GRP1-associated scaffold protein, GRIP associated protein 1, GRIP1 associated protein 1, GRIPAP 1, General receptor for phosphoinositides 1-associated scaffold protein

GRASP

Q9JJA9

Human, Mouse

This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids near the amino terminus of mouse Tamalin protein.

ELISA, IP, WB

Cell Biology, Cell Cycle, Cell Division, Organelles, Subcellular Markers, Tags & Cell Markers

This affinity purified antibody is directed against mouse Tamalin protein. The product was affinity purified from monospecific antiserum by immunoaffinity chromatography. A BLAST analysis was used to suggest cross-reactivity with Tamalin protein from rat based on a 94% homology with the immunizing sequence. Reactivity against homologues from other sources is not known.

1.03 mg/mL by UV absorbance at 280 nm

Liquid (sterile filtered)

Plays a role in intracellular trafficking and contributes to the macromolecular organization of group 1 metabotropic glutamate receptors (mGluRs) at synapses.

Dry Ice Shipping

Store vial at -20°C prior to opening. Aliquot contents and freeze at -20°C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4°C as an undiluted liquid. Dilute only prior to immediate use. Expiration date is one (1) year from date of opening.

https://www.bosterbio.com/msds?sku=A11078

42623 MW

General receptor for phosphoinositides 1-associated scaffold protein

Cytoplasm, perinuclear region. Cell membrane ; Peripheral membrane protein ; Cytoplasmic side. Cell junction, synapse, postsynaptic cell membrane. Localized at postsynaptic membranes.

IgG

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2, 0.01% (w/v) Sodium Azide