Anti-TCF7L2 Konijn Monoklonale Antilichaam

Boster Bio Anti-TCF7L2 Rabbit Monoclonal Antibody catalog # M00431. Tested in WB, IHC, ICC/IF, IP, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

Transcription factor 7-like 2; HMG box transcription factor 4; T-cell-specific transcription factor 4; T-cell factor 4; TCF-4; hTCF-4; TCF7L2; TCF4

TCF7L2

6934

Q9NQB0

Human, Mouse, Rat

A synthesized peptide derived from human TCF7L2

Clone: FIB-20

Detected in epithelium from small intestine, with the highest expression at the top of the crypts and a gradient of expression from crypt to villus. Detected in colon epithelium and colon cancer, and in epithelium from mammary gland and carcinomas derived therefrom. .

WB, IHC, ICC, IF, IP, Flow Cytometry

Atherosclerosis, Cardiovascular, Diabetes-associated, Domain Families, Epigenetics and Nuclear Signaling, Metabolism, Obesity, Transcription

Affinity-chromatography

0.5mg/ml

Liquid

Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M00431

67919 MW

160-180 kDa

Transcription factor 7-like 2

Nucleus, PML body . Diffuse pattern. Colocalizes with SUMO1 and PIAS4 in a subset of PML (promyelocytic leukemia) nuclear bodies.

T-cell surface glycoprotein CD4

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.