Anti-TCPTP/PTPN2 Antibody Picoband® fluoro550 Vervoeging

TCPTP is also called as PTPN2. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggested the roles in growth factor mediated cell signaling. Multiple alternatively spliced transcript variants encoding different isoforms have been found. Two highly related but distinctly processed pseudogenes that localize to chromosomes 1 and 13, respectively, have been reported.

Multidrug resistance-associated protein 4; ATP-binding cassette sub-family C member 4; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; MOAT-B; ABCC4; MRP4

PTPN2

5771

P17706

Human

No cross-reactivity with other proteins.

E.coli-derived human TCPTP/PTPN2 recombinant protein (Position: M1-R255) .

Widely expressed, with particularly high levels in prostate, but is barely detectable in liver.

Flow Cytometry

ATPases, Cancer, Channels, Drug Metabolism, Metabolism, Plasma Membrane, Signal Transduction

Immunogen affinity purified.

Liquid

May be an organic anion pump relevant to cellular detoxification.

1. Entrez Gene: PTPN2 protein tyrosine phosphatase, non-receptor type 2. 2. Brown-Shimer S, Johnson KA, Lawrence JB, Johnson C, Bruskin A, Green NR, Hill DE (Aug 1990) . Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B. Proc Natl Acad Sci U S A 87 (13) : 5148–52.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

149527 MW

6

Multidrug resistance-associated protein 4

Membrane; Multi-pass membrane protein.

Multidrug resistance-associated protein 4

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.