Anti-TDP43 Konijn Monoklonale Antilichaam

Boster Bio Anti-TDP43 Rabbit Monoclonal Antibody catalog # M01001-2. Tested in WB, IHC, ICC, IF, Flow Cytometry applications. This antibody reacts with Human, Mouse, Rat.

TAR DNA-binding protein 43; TDP-43; TARDBP; TDP43

TARDBP

23435

Q13148

Human, Mouse, Rat

A synthesized peptide derived from TDP43

Clone: 26T75

Ubiquitously expressed. In particular, expression is high in pancreas, placenta, lung, genital tract and spleen.

WB, IHC, ICC, IF, Flow Cytometry

Alzheimer's Disease, Cancer, Cancer Metabolism, Cardiovascular, Energy Transfer Pathways, Fatty Acid Oxidation, Fatty Acids, Integration Of Energy, Integration Of Energy Metabolism, Lipid and Lipoprotein Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathway, Metabolic Signaling Pathways, Metabolism, Metabolism Processes, Neurodegenerative Disease, Neurology Process, Neuroscience, Pathways and Processes, Protein Phosphorylation, Redox Metabolism, Response To Hypoxia, Ser/Thr Kinases, Signal Transduction

Affinity-chromatography

0.5mg/ml

Liquid

DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a interaction with the 3' UTR. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M01001-2

44740 MW

45 kDa

TAR DNA-binding protein 43

Nucleus . In patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis, it is absent from the nucleus of affected neurons but it is the primary component of cytoplasmic ubiquitin-positive inclusion bodies.

Glycogen synthase kinase-3 beta (gsk3b)

IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.