Anti-TEM4 ARHGEF17 Antilichaam

Rho GTPases, which are activated by specific guanine-nucleotide exchange factors (GEFs), play pivotal roles in several cellular functions. TEM4, encoding a protein containing 1510 amino acids, contains a RhoGEF-specific Dbl homology (DH) domain but lacks their typical pleckstrin homology domain. TEM4 is a Rho-specific GEF with novel structural and regulatory properties and predominant expression in the heart. It couples tyrosine kinase signals with the activation of the rho/rac GTPases, thus leading to cell differentiation and/or proliferation. Elevated levels of TEM4, TEM5, TEM6, TEM7 and TEM7R were also raised in breast cancer tissues. TEM4 could also prove to be useful targets therapeutically.

Boster Bio Anti-TEM4 ARHGEF17 Antibody (Catalog # A10510) . Tested in ELISA, WB, IHC-P applications. This antibody reacts with Human.

TEM4, P164RHOGEF, p164-RhoGEF, KIAA0337, TEM4, Rho guanine nucleotide exchange factor 17, 164 kDa Rho-specific guanine-nucleotide exchange factor

ARHGEF17

Q96PE2

Human

TEM4 antibody was raised against a 18 amino acid synthetic peptide near the center of human TEM4. The immunogen is located within amino acids 910 - 960 of TEM4.

Highly expressed in the heart.

ELISA, WB, IHC-P

Homeostasis

TEM4 Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Acts as guanine nucleotide exchange factor (GEF) for RhoA GTPases.

TEM4 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

https://www.bosterbio.com/msds?sku=A10510

221673 MW

Rho guanine nucleotide exchange factor (GEF) 17

Cell membrane ; Lipid-anchor .

Mouse

Rho guanine nucleotide exchange factor (GEF) 17

IgG

TEM4 Antibody is supplied in PBS containing 0.02% sodium azide.