Anti-Teneurin-3 (N497/10) Recombinant kip Chimeric mAb FL490 Conjugate

Teneurin-3 is a large type II transmembrane protein belonging to the teneurin family, which plays essential roles in neuronal connectivity, cell adhesion, and developmental patterning. Structurally, Teneurin-3 contains a large extracellular domain with EGF-like repeats, NHL and YD-repeat motifs, and a unique C-terminal peptide sequence implicated in intercellular signaling. It mediates homophilic and heterophilic interactions that guide axon targeting and synapse specificity, particularly in the visual and hippocampal systems. Teneurin-3 interacts with latrophilins and other synaptic adhesion molecules to regulate synaptogenesis and neuronal circuit formation. Genetic disruption or altered expression of TENM3 has been linked to neurodevelopmental disorders, visual pathway defects, and certain cancers, highlighting its significance in neural development and disease.

Our chicken Anti-Teneurin-3 recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone N497/10. It detects human, mouse, and rat Teneurin-3, and is purified by affinity chromatography. It is great for use in ICC, IHC.

Our chicken Anti-Teneurin-3 recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone N497/10. It detects human, mouse, and rat Teneurin-3, and is purified by affinity chromatography. It is great for use in ICC, IHC.

Tenm3

Tenm3

Human, Mouse, and Rat

Recombinant protein comprising amino acids aa 161-201 and 343-396 (extracellular and cytoplasmic domains) of mouse Teneurin-3 (Tenm3, accession number Q9WTS6) connected by a Gly8 linker, produced recombinantly in E.Coli.

Teneurin-3

N497/10

FL490 Ex: 491 nm, Em: 515 nm

ICC, IHC

Cell Adhesion Molecules

Primary Antibodies

0.5 mg/mL

Purified by affinity chromatography

Liquid

7.4

303 kDa

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Shipped on ice packs

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone N497/10 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N497/10 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and conjugated.

No cross-reactivity reported

Each new lot of antibody is quality control tested by Western blot on rat brain membrane fraction and confirmed to stain the expected molecular weight band.

Q9WTS6

IgY

Mouse

Quality Control: WB Brain