Anti-TFIIH p44 GTF2H2 Antilichaam

Boster Bio Anti-TFIIH p44 GTF2H2 Antibody catalog # A08466. Tested in WB, IHC, IF, ELISA applications. This antibody reacts with Human, Mouse, Rat.

General transcription factor IIH subunit 2; Basic transcription factor 2 44 kDa subunit; BTF2 p44

GTF2H2

Q13888

Human, Mouse, Rat

The antiserum was produced against synthesized peptide derived from human TF2H2. AA range:1-50

Widely expressed, with higher expression in skeletal muscle.

WB, IHC, IF, ELISA

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

1 mg/mL

Liquid

Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre- initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription. The N-terminus of GTF2H2 interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter.

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=A08466

44419 MW

General transcription factor IIH subunit 2

Nucleus

General transcription factor IIH subunit 2

IgG

Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.