Anti-TFPI2 Antibody Picoband® fluoro488 Vervoeging

Tissue factor pathway inhibitor 2, also known as TFPI2, is a human gene which is located at 7q22. It is an important regulator of the extrinsic pathway of blood coagulation through its ability to inhibit factor Xa and factor VIIa-tissue factor activity. After a 22-residue signal peptide, the mature TFPI2 protein contains 213 amino acids with 18 cysteines and 2 canonical N-linked glycosylation sites. The purified recombinant TFPI2 strongly inhibited the amidolytic activities of trypsin and the factor VIIa-tissue factor complex. The latter inhibition was markedly enhanced in the presence of heparin. Mouse TFPI2 mRNA is highly expressed in developing mouse placenta, as in human. And there are also high transcript levels in adult mouse liver and kidney.

Tissue factor pathway inhibitor 2; TFPI-2; Placental protein 5; PP5; TFPI2

TFPI2

7980

P48307

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of human TFPI2.

Umbilical vein endothelial cells, liver, placenta, heart, pancreas, and maternal serum at advanced pregnancy.

Flow Cytometry

Cardiovascular, Cell Biology, Protease Inhibitors, Proteolysis/Ubiquitin

Immunogen affinity purified.

Liquid

May play a role in the regulation of plasmin-mediated matrix remodeling. Inhibits trypsin, plasmin, factor VIIa/tissue factor and weakly factor Xa. Has no effect on thrombin. .

1. Sprecher, C. A.; Kisiel, W.; Mathewes, S.; Foster, D. C. : Molecular cloning, expression, and partial characterization of a second human tissue-factor-pathway inhibitor. Proc. Nat. Acad. Sci. 91: 3353-3357, 1994. 2. Miyagi, Y.; Yasumitsu, H.; Mizushima, H.; Koshikawa, N.; Matsuda, Y.; Itoh, H.; Hori, T.-A.; Aoki, I.; Misugi, K.; Miyazaki, K. : Cloning of the cDNA encoding mouse PP5/TFPI-2 and mapping of the gene to chromosome 6. DNA and Cell Biology 15: 947-954, 1996.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

26934 MW

No cross reactivity with other proteins.

6

Tissue factor pathway inhibitor 2

Secreted.

Belongs to the nuclear hormone receptor family. NR1 subfamily.

Tissue factor pathway inhibitor 2 (TFPI-2)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.