Anti-TGF-alfa/TGFA Antibody Picoband® fluoro594

Transforming growth factor alpha (TGF-alpha) is upregulated in some human cancers. It is produced in macrophages, brain cells, and keratinocytes, and induces epithelial development. It is closely related to EGF, and can also bind to the EGF receptor with similar effects . TGFalpha stimulates neural cell proliferation in the adult injured brain. TGFalpha was cited in the 2001 NIH Stem Cell report to the U.S. Congress as promising evidence for the ability of adult stem cells to restore function in neurodegenerative disorders.

Protransforming growth factor alpha; Transforming growth factor alpha; TGF-alpha; EGF-like TGF; ETGF; TGF type 1; TGFA

TGFA

7039

P01135

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human TGF alpha, different from the related mouse and rat sequences by one amino acid.

Isoform 1, isoform 3 and isoform 4 are expressed in keratinocytes and tumor-derived cell lines. .

Flow Cytometry

Angiogenesis, Cancer, Cardiovascular, Growth Factors, Growth Factors/Hormones, Invasion/Microenvironment, Signal Transduction

Immunogen affinity purified.

Liquid

TGF alpha is a mitogenic polypeptide that is able to bind to the EGF receptor/EGFR and to act synergistically with TGF beta to promote anchorage-independent cell proliferation in soft agar.

1. In vivo induction of massive proliferation, ed migration, and differentiation of neural cells in the adult mammalian brain.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

17006 MW

No cross reactivity with other proteins.

6

Protransforming growth factor alpha

Transforming growth factor alpha: Secreted, extracellular space.

Protransforming growth factor alpha

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.