Anti-THEMIS Antibody Picoband®

This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants.

Boster Bio Anti-THEMIS Antibody Picoband® catalog # A07854-3. Tested in ELISA, Flow Cytometry, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

Fascin-2; Retinal fascin; FSCN2

THEMIS

387357

Q8N1K5

Human

No cross-reactivity with other proteins.

E.coli-derived human THEMIS recombinant protein (Position: Q74-H588) .

Localized specifically in the outer and inner segments of the photoreceptor cells in the retina.

WB, Flow Cytometry, ELISA

Golgi Proteins, Protein Trafficking, Signal Transduction, Vesicle Transport

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.

1. Fu, G., Casas, J., Rigaud, S., Rybakin, V., Lambolez, F., Brzostek, J., Hoerter, J. A. H., Paster, W., Acuto, O., Cheroutre, H., Sauer, K., Gascoigne, N. R. J. Themis sets the signal threshold for positive and negative selection in T-cell development. Nature 504: 441-445, 2013. 2. Fu, G., Vallee, S., Rybakin, V., McGuire, M. V., Ampudia, J., Brockmeyer, C., Salek, M., Fallen, P. R., Hoerter, J. A. H., Munshi, A., Huang, Y. H., Hu, J., Fox, H. S., Sauer, K., Acuto, O., Gascoigne, N. R. J. Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nature Immun. 10: 848-856, 2009. 3. Johnson, A. L., Aravind, L., Shulzhenko, N., Morgun, A., Choi, S.-Y., Crockford, T. L., Lambe, T., Domaschenz, H., Kucharska, E. M., Zheng, L., Vinuesa, C. G., Lenardo, M. J., Goodnow, C. C., Cornall, R. J., Schwartz, R. H. Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection. Nature Immun. 10: 831-839, 2009. Note: Erratum: Nature Immun. 11: 97 only, 2010.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A07854-3

49229 MW

73 kDa

6

Fascin actin-bundling protein 2, retinal

Nucleus.

Chromaffin granule amine transporter

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.