Anti-THEMIS Antibody Picoband® fluoro488 Vervoeging

This gene encodes a protein that plays a regulatory role in both positive and negative T-cell selection during late thymocyte development. The protein functions through T-cell antigen receptor signaling, and is necessary for proper lineage commitment and maturation of T-cells. Alternative splicing results in multiple transcript variants.

Fascin-2; Retinal fascin; FSCN2

THEMIS

387357

Q8N1K5

Human

No cross-reactivity with other proteins.

E.coli-derived human THEMIS recombinant protein (Position: Q74-H588) .

Localized specifically in the outer and inner segments of the photoreceptor cells in the retina.

Flow Cytometry

Golgi Proteins, Protein Trafficking, Signal Transduction, Vesicle Transport

Immunogen affinity purified.

Liquid

Acts as an actin bundling protein. May play a pivotal role in photoreceptor cell-specific events, such as disk morphogenesis.

1. Fu, G., Casas, J., Rigaud, S., Rybakin, V., Lambolez, F., Brzostek, J., Hoerter, J. A. H., Paster, W., Acuto, O., Cheroutre, H., Sauer, K., Gascoigne, N. R. J. Themis sets the signal threshold for positive and negative selection in T-cell development. Nature 504: 441-445, 2013. 2. Fu, G., Vallee, S., Rybakin, V., McGuire, M. V., Ampudia, J., Brockmeyer, C., Salek, M., Fallen, P. R., Hoerter, J. A. H., Munshi, A., Huang, Y. H., Hu, J., Fox, H. S., Sauer, K., Acuto, O., Gascoigne, N. R. J. Themis controls thymocyte selection through regulation of T cell antigen receptor-mediated signaling. Nature Immun. 10: 848-856, 2009. 3. Johnson, A. L., Aravind, L., Shulzhenko, N., Morgun, A., Choi, S.-Y., Crockford, T. L., Lambe, T., Domaschenz, H., Kucharska, E. M., Zheng, L., Vinuesa, C. G., Lenardo, M. J., Goodnow, C. C., Cornall, R. J., Schwartz, R. H. Themis is a member of a new metazoan gene family and is required for the completion of thymocyte positive selection. Nature Immun. 10: 831-839, 2009. Note: Erratum: Nature Immun. 11: 97 only, 2010.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

49229 MW

6

Fascin actin-bundling protein 2, retinal

Nucleus.

Chromaffin granule amine transporter

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.