Anti-TIM 4/TIMD4 Antibody Picoband® fluoro594 Vervoeging

T-cell immunoglobulin and mucin domain containing 4 (TIMD-4) also known as T-cell membrane protein 4 (TIM-4) is a protein in humans that is encoded by the TIMD4 gene.

Pancreatic secretory granule membrane major glycoprotein GP2; Pancreatic zymogen granule membrane protein GP-2; Gp2

TIMD4

91937

Q96H15

Human

No cross-reactivity with other proteins.

E.coli-derived human TIM 4/TIMD4 recombinant protein (Position: S24-L378) .

Expressed in all tissues tested including, liver, heart, adipose tissue, mammary gland, testes, ovary, brain, kidney and muscle. Highest levels in liver.

Flow Cytometry

Cofactors, Vitamins/Minerals, Metabolism, Mitochondrial, Mitochondrial Markers, Mitochondrial Metabolism, Pathways and Processes, Signal Transduction, Vitamins/Minerals

Immunogen affinity purified.

Liquid

Functions as a transcriptional repressor, inhibiting the signaling of retinoic acid through the retinoic acid receptors RARA, RARB and RARG. Prevents retinoic acid-induced cell proliferation arrest, differentiation and apoptosis.

1. Czuczman, M. A., Fattouh, R., van Rijn, J. M., Canadien, V., Osborne, S., Muise, A. M., Kuchroo, V. K., Higgins, D. E., Brumell, J. H. Listeria monocytogenes exploits efferocytosis to promote cell-to-cell spread. Nature 509: 230-234, 2014. 2. Kuchroo, V. K., Umetsu, D. T., DeKruyff, R. H., Freeman, G. J. The TIM gene family: emerging roles in immunity and disease. Nature Rev. Immun. 3: 454-462, 2003. 3. Meyers, J. H., Chakravarti, S., Schlesinger, D., Illes, Z., Waldner, H., Umetsu, S. E., Kenny, J., Zheng, X. X., Umetsu, D. T., DeKruyff, R. H., Strom, T. B., Kuchroo, V. K. TIM-4 is the ligand for TIM-1, and the TIM-1-TIM-4 interaction regulates T cell proliferation. Nature Immun. 6: 455-464, 2005.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

104553 MW

6

Glycoprotein 2 (zymogen granule membrane)

Cell membrane. GPI-anchor. Secreted.

AP-2 complex subunit beta

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.