Anti-Tlr5 Antibody Picoband® 31.0550 Vervoeging

Toll-like receptor 5, also known as TLR5, is a protein which in humans is encoded by the TLR5 gene. Predicted to enable interleukin-1 receptor binding activity and signaling receptor activity. Predicted to be involved in several processes, including positive regulation of interleukin-8 production; positive regulation of nitric oxide biosynthetic process; and positive regulation of toll-like receptor signaling pathway. Predicted to act upstream of or within innate immune response. Predicted to be located in membrane. Predicted to be integral component of plasma membrane. Is expressed in brain; olfactory epithelium; spinal cord; and trunk unsegmented mesenchyme. Human ortholog (s) of this gene implicated in Legionnaires' disease; cystic fibrosis; cystitis; melioidosis; and systemic lupus erythematosus. Orthologous to human TLR5 (toll like receptor 5) .

Beta-2-microglobulin; B2m

Tlr5

53791

Q9JLF7

Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived mouse Tlr5 recombinant protein (Position: Q81-D766) .

Detected in lung, spleen, uterus, vagina and epididymis. .

Flow Cytometry

Immunoglobulins, Immunology

Immunogen affinity purified.

Liquid

Component of the class I major histocompatibility complex (MHC) . Involved in the presentation of peptide antigens to the immune system.

1. Andersen-Nissen, E., Hawn, T. R., Smith, K. D., Nachman, A., Lampano, A. E., Uematsu, S., Akira, S., Aderem, A. Cutting edge: Tlr5-/- mice are more susceptible to Escherichia coli urinary tract infection. J. Immun. 178: 4717-4720, 2007. 2. Andersen-Nissen, E., Smith, K. D., Bonneau, R., Strong, R. K., Aderem, A. A conserved surface on Toll-like receptor 5 recognizes bacterial flagellin. J. Exp. Med. 204: 393-403, 2007. 3. Burdelya, L. G., Krivokrysenko, V. I., Tallant, T. C., Strom, E., Gleiberman, A. S., Gupta, D., Kurnasov, O. V., Fort, F. L., Osterman, A. L., DiDonato, J. A., Feinstein, E., Gudkov, A. V. An agonist of Toll-like receptor 5 has radioprotective activity in mouse and primate models. Science 320: 226-230, 2008.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

22875 MW

6

Beta-2 microglobulin

Secreted . Upon binding to the SLC22A17 (24p3R) receptor, it is internalized.

Neutrophil gelatinase-associated lipocalin

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.