Anti-TMC7 Antibody Picoband® 31.0550 Vervoeging

Predicted to enable mechanosensitive ion channel activity. Predicted to be involved in ion transmembrane transport. Predicted to be integral component of plasma membrane.

Interactor of HORMAD1 protein 1; Cancer/testis antigen 74; CT74; Coiled-coil domain-containing protein 36; CCDC36; IHO1

TMC7

79905

Q7Z402

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human TMC7 recombinant protein (Position: A8-N723) .

Detected in liver, skeletal muscle, kidney, pancreas, spleen, thyroid, testis, ovary, small intestine and colon.

Flow Cytometry

Cell Biology

Immunogen affinity purified.

Liquid

Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with MEI4 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis. Not required for HORMAD1 functions in pairing-independent synaptonemal complex formation, ATR recruitment to unsynapsed axes, meiotic silencing of unsynapsed chromatin (MSUC) or meiotic surveillance.

1. Keresztes, G., Mutai, H., Heller, S. The TMC and EVER genes belong to a larger protein family, the TMC gene family encoding transmembrane proteins. BMC Genomics 4: 24, 2003. Note: Electronic Article. 2. Kurima, K., Yang, Y., Sorber, K., Griffith, A. J. Characterization of the transmembrane channel-like (TMC) gene family: functional clues from hearing loss and epidermodysplasia verruciformis. Genomics 82: 300-308, 2003.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

64099 MW

6

Coiled-coil domain containing 36

Chromosome.

DAP3 binding cell death enhancer 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.